Article
Genetic variations in relation to bleeding and pharmacodynamics of dabigatran in Chinese patients with nonvalvular atrial fibrillation: A nationwide multicentre prospective cohort study.
Clinical and translational medicine - 1 Dec 2022
Xiang Qian, Xie Qiufen, Liu Zhiyan, Mu Guangyan, Zhang Hanxu, Zhou Shuang, Wang Zhe, Wang Zining, Zhang Yatong, Zhao Zinan, Yuan Dongdong, Guo Liping, Wang Na, Xiang Jing, Song Hongtao, Sun Jianjun, Jiang Jie, Cui Yimin
Abstract excerpt
INTRODUCTION: To identify the potential factors responsible for the individual variability of dabigatran, we investigated the genetic variations associated with clinical outcomes and pharmacodynamics (PD) in Chinese patients with nonvalvular atrial fibrillation (NVAF). MATERIALS AND METHODS: Chinese patients with NVAF taking dabigatran etexilate with therapeutic doses were enrolled. The primary (bleeding events)...
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