Article
Identification of single nucleotide polymorphisms (SNPs) associated with chronic graft-versus-host disease in patients undergoing allogeneic hematopoietic cell transplantation.
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer - 21 Sept 2023
Mougeot Jean-Luc C, Beckman Micaela F, Hovan Allan J, Hasséus Bengt, Legert Karin Garming, Johansson Jan-Erik, von Bültzingslöwen Inger, Brennan Michael T, Bahrani Mougeot Farah
Abstract excerpt
INTRODUCTION: Chronic graft-versus-host disease (cGVHD) is a debilitating side effect of allogeneic hematopoietic cell transplantation (HCT), affecting the quality of life of patients. We used whole exome sequencing to identify candidate SNPs and complete a multi-marker gene-level analysis using a cohort of cGVHD( +) (N = 16) and cGVHD( -) (N = 66) HCT patients. METHODS: Saliva samples were collected from HCT...
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