Article
Genome-wide association study reveals two novel genetic loci associated with chronic lung allograft dysfunction.
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation - 1 Sept 2026
Brocard Simon, Mauduit Vincent, Morin Martin, Boussamet Léo, Silva Nayane Dos Santos Brito, Durand Axelle, Halitim Pierre, Renaud-Picard Benjamin, Coiffard Benjamin, Demant Xavier, Falque Loïc, Le Pavec Jérome, Roux Antoine, Villeneuve Thomas, Knoop Christiane, Merveilleux Claire, Salpin Mathilde, Carlier Nicolas, Gourraud Pierre Antoine, Magnan Antoine, Lair David, Berthelot Laureline, Südholt Mario, Vince Nicolas, Tissot Adrien, Limou Sophie
Abstract excerpt
BACKGROUND: Chronic lung allograft dysfunction (CLAD) leads to declining respiratory function and high mortality, representing the main barrier to long-term survival in lung transplantation (LT). We performed the first genome-wide association study (GWAS) investigating donor's and recipient's genetic factors associated with CLAD. METHOD: We genotyped 392 donor-recipient pairs from the multicentric Cohort in Lung...
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