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Genetic susceptibility to acute graft versus host disease in pediatric patients undergoing HSCT.

Bone marrow transplantation - 1 Nov 2021

Ansari Marc, Petrykey Kateryna, Rezgui Mohamed Aziz, Del Vecchio Veronica, Cortyl Jacques, Ameur Milad, Nava Tiago, Beaulieu Patrick, St-Onge Pascal, Mlakar Simona Jurkovic, Uppugunduri Chakradhara Rao S, Théoret Yves, Bartelink Imke H, Boelens Jaap-Jan, Bredius Robbert G M, Dalle Jean-Hugues, Lewis Victor, Kangarloo Bill S, Corbacioglu Selim, Sinnett Daniel, Bittencourt Henrique, Krajinovic Maja

Abstract excerpt

The most frequent complication of allogeneic hematopoietic stem cell transplantation is acute Graft versus Host Disease (aGVHD). Proliferation and differentiation of donor T cells initiate inflammatory response affecting the skin, liver, and gastrointestinal tract. Besides recipient-donor HLA disparities, disease type, and the conditioning regimen, variability in the non-HLA genotype have an impact on aGVHD...

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PMID: 34215854
DOI: 10.1038/s41409-021-01386-8

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