Article
Single nucleotide polymorphisms conferring susceptibility to leukemia and oral mucositis: a multi-center pilot study of patients prior to conditioning therapy for hematopoietic cell transplant.
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer - 11 Mar 2024
Mougeot Jean-Luc C, Beckman Micaela F, Alexander Adam S, Hovan Allan J, Hasséus Bengt, Legert Karin Garming, Johansson Jan-Erik, von Bültzingslöwen Inger, Brennan Michael T, Mougeot Farah Bahrani
Abstract excerpt
PURPOSE: Leukemias have been associated with oral manifestations, reflecting susceptibility to cancer therapy-induced oral mucositis. We sought to identify SNPs associated with both leukemia and oral mucositis (OM). METHODS: Whole exome sequencing was performed on leukemia and non-cancer blood disorder (ncBD) patients' saliva samples (N = 50) prior to conditioning therapy. WHO OM grading scores were determined:...
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