Article
Defining genetic risk for graft-versus-host disease and mortality following allogeneic hematopoietic stem cell transplantation.
Current opinion in hematology - 1 Nov 2010
Hansen John A, Chien Jason W, Warren Edus H, Zhao Lue Ping, Martin Paul J
Abstract excerpt
PURPOSE OF REVIEW: This review explores what is known about the genetics of hematopoietic stem cell transplantation (HCT) and how genetic polymorphism affects risk of graft-versus-host disease (GVHD) and mortality. RECENT FINDINGS: Genetic variation found across the human genome can impact HCT outcome by causing genetic disparity between patient and donor and modifying gene function. Single nucleotide...
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