Genome-scale functional mapping of the mammalian whole brain with in vivo Perturb-seq

Abstract excerpt

Functional genomics studies have provided critical insights into cell type-specific gene regulatory programs, but to date most have been conducted in wild-type tissues or cell cultures. Here, we present a gene expression functional atlas across the mouse brain. We use an enhanced in vivo Perturb-seq platform to analyze transcriptome-wide responses to loss of 1,947 disease-associated genes, profiling over 7.7 milli...

Topics

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• Chromatin
• Chromatin Assembly and Disassembly
• Gene Expression Regulation
• Nervous System Diseases
• Neuroglia
• Neurons
• Regulatory Sequences, Nucleic Acid
• Single-Cell Analysis

Identifiers and source

Literature Corpus work

67eb7cf3-1b29-595d-a4d7-5832eab48763

DOI

10.64898/2026.03.16.711480