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A CRISPR-engineered Isogenic Model Reveals Altered Neuronal Phenotypes of the 22q11.2 A-B Syndromic Deletion

2022-06-24

Abstract excerpt

<h4>ABSTRACT</h4> The 22q11.2 deletion syndrome (22q11.2DS), associated with congenital and neuropsychiatric anomalies, is the most common copy number variant (CNV)-associated syndrome. Patient-derived, induced pluripotent stem cell (iPS) models have provided important insight into the mechanisms of phenotypic features of this condition. However, patient-derived iPS models may harbor underlying genetic heterogene...

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Literature Corpus work: b864c11d-6016-52f9-a197-a638b11dfcc9
DOI: 10.1101/2022.06.22.497212

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