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Article

A strategy for evaluating potential antiviral resistance to small molecule drugs and application to SARS-CoV-2.

Scientific reports - 10 Jan 2023

Sargsyan Karen, Mazmanian Karine, Lim Carmay

Abstract excerpt

Alterations in viral fitness cannot be inferred from only mutagenesis studies of an isolated viral protein. To-date, no systematic analysis has been performed to identify mutations that improve virus fitness and reduce drug efficacy. We present a generic strategy to evaluate which viral mutations might diminish drug efficacy and applied it to assess how SARS-CoV-2 evolution may affect the efficacy of current...

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Identifiers

PMID: 36627366
DOI: 10.1038/s41598-023-27649-6
PMCID: PMC9831016

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