Article
The mutation rate of SARS-CoV-2 is highly variable between sites and is influenced by sequence context, genomic region, and RNA structure.
Nucleic acids research - 6 Jun 2025
Haddox Hugh K, Angehrn Georg, Sesta Luca, Jennings-Shaffer Chris, Temple Seth D, Galloway Jared G, Hinrichs Angie S, DeWitt William S, Bloom Jesse D, Iv Frederick A Matsen, Neher Richard A
Abstract excerpt
RNA viruses like SARS-CoV-2 have high mutation rates, which contribute to their rapid evolution. Mutation rates depend on mutation type and can vary between sites in a virus's genome. Understanding this variation can shed light on the mutational processes at play, and is crucial for quantitative modeling of viral evolution. Using millions of SARS-CoV-2 full-genome sequences, we estimate rates of synonymous...
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