Article
Analysis of 6.4 million SARS-CoV-2 genomes identifies mutations associated with fitness.
Science (New York, N.Y.) - 17 Jun 2022
Obermeyer Fritz, Jankowiak Martin, Barkas Nikolaos, Schaffner Stephen F, Pyle Jesse D, Yurkovetskiy Leonid, Bosso Matteo, Park Daniel J, Babadi Mehrtash, MacInnis Bronwyn L, Luban Jeremy, Sabeti Pardis C, Lemieux Jacob E
Abstract excerpt
Repeated emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants with increased fitness underscores the value of rapid detection and characterization of new lineages. We have developed PyR0, a hierarchical Bayesian multinomial logistic regression model that infers relative prevalence of all viral lineages across geographic regions, detects lineages increasing in prevalence, and...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.