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Article

DNA methylation near the INS gene is associated with INS genetic variation (rs689) and type 1 diabetes in the Diabetes Autoimmunity Study in the Young.

Pediatric diabetes - 1 Jun 2020

Carry Patrick M, Vanderlinden Lauren A, Johnson Randi K, Dong Fran, Steck Andrea K, Frohnert Brigitte I, Rewers Marian, Yang Ivana V, Kechris Katerina, Norris Jill M

Abstract excerpt

OBJECTIVE: Mechanisms underlying the role of non-human leukocyte antigen (HLA) genetic risk variants in type 1 diabetes (T1D) are poorly understood. We aimed to test the association between methylation and non-HLA genetic risk. METHODS: We conducted a methylation quantitative trait loci (mQTL) analysis in a nested case-control study from the Dietary Autoimmunity Study in the Young. Controls (n = 83) were...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32061050
DOI: 10.1111/pedi.12995
PMCID: PMC7378362

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