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Article

DNA methylation profiles in type 1 diabetes twins point to strong epigenetic effects on etiology.

Journal of autoimmunity - 1 May 2014

Stefan Mihaela, Zhang Weijia, Concepcion Erlinda, Yi Zhengzi, Tomer Yaron

Abstract excerpt

Type 1 diabetes (T1D) shows ∼40% concordance rate in monozygotic twins (MZ) suggesting a role for environmental factors and/or epigenetic modifications in the etiology of the disease. The aim of our study was to dissect the contribution of epigenetic factors, particularly, DNA methylation (DNAm), to the incomplete penetrance of T1D. We performed DNAm profiling in lymphocyte cell lines from 3 monozygotic (MZ) twin...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24210274
DOI: 10.1016/j.jaut.2013.10.001
PMCID: PMC3995844

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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