Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

No association between IRS‑1 promoter methylation and type 2 diabetes.

Molecular medicine reports - 1 Sept 2013

Ma Jiangbo, Cheng Jia, Wang Lingyan, Wang Hongwei, Xu Leiting, Liu Panpan, Bu Shizhong, Zhang Lina, Le Yanping, Ye Meng, Wang Qinwen, Shi Yuping, Duan Shiwei

Abstract excerpt

As a candidate gene for type 2 diabetes (T2D), insulin receptor substrate-1 (IRS‑1) gene variations were found to be associated with the risk of T2D. The aim of our study was to investigate the contribution of promoter DNA methylation of the IRS‑1 gene to the risk of T2D. Using bisulphite pyrosequencing technology, the DNA methylation levels of 3 CpG dinucleotides within the IRS‑1 gene promoter were measured in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CpG Islands
Share to Diabetes Mellitus, Type 2

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Methylation

Share to Insulin Receptor Substrate Proteins

Share to Promoter Regions, Genetic

Share to Risk Factors

Share to Sequence Analysis, DNA

Share to Sex Factors

Source

Identifiers

PMID: 23828647
DOI: 10.3892/mmr.2013.1569

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

No association between IRS‑1 promoter methylation and type 2 diabetes.PMID 23828647Read ↗

DNA methylation profiles in type 1 diabetes twins point to strong epigenetic effects on etiology.Semantic proximity Read ↗

DNA Methylation and Type 2 Diabetes: Novel Biomarkers for Risk Assessment?Semantic proximity Read ↗

DNA methylation in the pathogenesis of type 2 diabetes in humansSemantic proximity Read ↗

DNA Methylation as a Diagnostic and Therapeutic Target in the Battle Against Type 2 DiabetesSemantic proximity Read ↗

Hypomethylation within gene promoter regions and type 1 diabetes in discordant monozygotic twins.Semantic proximity Read ↗

DNA methylation differences within INS, PTPN22 and IL2RA promoters in lymphocyte subsets in children with type 1 diabetes and controls.Semantic proximity Read ↗

Association of the CpG Methylation Pattern of the Proximal Insulin Gene Promoter with Type 1 DiabetesSemantic proximity Read ↗

DNA methylation of loci within <i>ABCG1 </i>and <i>PHOSPHO1 </i>in blood DNA is associated with future type 2 diabetes riskSemantic proximity Read ↗

Increased DNA methylation levels of the insulin-like growth factor binding protein 1 gene are associated with type 2 diabetes in Swedish menSemantic proximity Read ↗

Multi-layered epigenetic regulation of IRS2 expression in the liver of obese individuals with type 2 diabetesSemantic proximity Read ↗

Does DNA Methylation of PPARGC1A Influence Insulin Action in First Degree Relatives of Patients with Type 2 Diabetes?Semantic proximity Read ↗

Global DNA Methylation Is Associated With Insulin ResistanceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.