Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Identification of loci where DNA methylation potentially mediates genetic risk of type 1 diabetes.

Journal of autoimmunity - 1 Sept 2018

Ye Jody, Richardson Tom G, McArdle Wendy L, Relton Caroline L, Gillespie Kathleen M, Suderman Matthew, Hemani Gibran

Abstract excerpt

The risk of Type 1 Diabetes (T1D) comprises both genetic and environmental components. We investigated whether genetic susceptibility to T1D could be mediated by changes in DNA methylation, an epigenetic mechanism that potentially plays a role in autoimmune diabetes. From enrichment analysis, we found that there was a common genetic influence for both DNA methylation and T1D across the genome, implying that...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CpG Islands
Share to CTLA-4 Antigen

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Diabetes Mellitus, Type 1

Share to DNA Methylation

Share to Epigenesis, Genetic

Share to Longitudinal Studies

Share to Mendelian Randomization Analysis

Share to Protein Tyrosine Phosphatase, Non-Receptor Type 2

Source

Identifiers

PMID: 30146008
DOI: 10.1016/j.jaut.2018.06.005

Genes

AFF3
CTLA4
CTSH
PTPN2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Identification of loci where DNA methylation potentially mediates genetic risk of type 1 diabetes.PMID 30146008Read ↗

DNA methylation profiles in type 1 diabetes twins point to strong epigenetic effects on etiology.Semantic proximity Read ↗

Genetic and epigenetic factors in etiology of diabetes mellitus type 1.Semantic proximity Read ↗

Increased DNA methylation variability in type 1 diabetes across three immune effector cell typesSemantic proximity Read ↗

Fine-mapping, trans-ancestral and genomic analyses identify causal variants, cells, genes and drug targets for type 1 diabetesSemantic proximity Read ↗

Elucidating the Epigenetic Landscape of Type 2 Diabetes: A Multi-Omics Analysis Revealing Novel CpG Sites and Their Association with Cardiometabolic TraitsSemantic proximity Read ↗

Identification of type 1 diabetes-associated DNA methylation variable positions that precede disease diagnosis.Semantic proximity Read ↗

Longitudinal DNA methylation differences precede type 1 diabetesSemantic proximity Read ↗

Genetic impacts on DNA methylation help elucidate regulatory genomic processesSemantic proximity Read ↗

Novel epigenetic determinants of type 2 diabetes in Mexican-American families.Semantic proximity Read ↗

Beyond Genetics: What Causes Type 1 Diabetes.Semantic proximity Read ↗

Type 1 diabetes: genes associated with disease developmentSemantic proximity Read ↗

Fine-mapping, trans-ancestral and genomic analyses identify causal variants, cells, genes and drug targets for type 1 diabetes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.