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Association of the CpG Methylation Pattern of the Proximal Insulin Gene Promoter with Type 1 Diabetes

2 May 2012

Abstract excerpt

The insulin (INS) region is the second most important locus associated with Type 1 Diabetes (T1D). The study of the DNA methylation pattern of the 7 CpGs proximal to the TSS in the INS gene promoter revealed that T1D patients have a lower level of methylation of CpG -19, -135 and -234 (p = 2.10(-16)) and a higher methylation of CpG -180 than controls, while methylation was comparable for CpG -69, -102, -206. The...

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PMID: 22567146
DOI: 10.1371/journal.pone.0036278

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Association of the CpG Methylation Pattern of the Proximal Insulin Gene Promoter with Type 1 DiabetesPMID 22567146Read ↗

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