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Article

Early DNA methylation changes in children developing beta cell autoimmunity at a young age

10 Feb 2022

Abstract excerpt

Abstract Aims/hypothesis Type 1 diabetes is a chronic autoimmune disease of complex aetiology, including a potential role for epigenetic regulation. Previous epigenomic studies focused mainly on clinically diagnosed individuals. The aim of the study was to assess early DNA methylation changes associated with type 1 diabetes already before the diagnosis or even before the appearance of autoantibodies. Methods...

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PMID: 35142878
DOI: 10.1007/s00125-022-05657-x

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