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Article

α-Helical element at the hormone-binding surface of the insulin receptor functions as a signaling element to activate its tyrosine kinase.

Proceedings of the National Academy of Sciences of the United States of America - 10 Jul 2012

Whittaker Jonathan, Whittaker Linda J, Roberts Charles T, Phillips Nelson B, Ismail-Beigi Faramarz, Lawrence Michael C, Weiss Michael A

Abstract excerpt

The primary hormone-binding surface of the insulin receptor spans one face of the N-terminal β-helix of the α-subunit (the L1 domain) and an α-helix in its C-terminal segment (αCT). Crystallographic analysis of the free ectodomain has defined a contiguous dimer-related motif in which the αCT α-he...

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Identifiers

PMID: 22736795
DOI: 10.1073/pnas.1205681109
PMCID: PMC3396503

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22736795-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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