Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The insulin-like growth factor mutation database (IGFmdb).

Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society - 1 Oct 2012

Rajapaksha Harinda, Alvino Clair, McCarthy Peter, Forbes Briony E

Abstract excerpt

Insulin-like growth factors (IGF-I and IGF-II), and insulin are evolutionarily conserved hormonal regulators of eukaryotic growth and development. Through interactions with their cognate receptors, all three molecules can influence cellular growth, proliferation, differentiation, migration, and survival, as well as metabolic processes. As such, perturbations in signaling by IGFs and insulin are a well-documented...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Databases, Factual
Share to Insulin-Like Growth Factor I

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Insulin-Like Growth Factor II

Share to Ligands

Share to Mutation

Share to Somatomedins

Source

Identifiers

PMID: 22698731
DOI: 10.1016/j.ghir.2012.05.001

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The insulin-like growth factor mutation database (IGFmdb).PMID 22698731Read ↗

RILM: a web-based resource to aid comparative and functional analysis of the insulin and IGF-1 receptor family.Semantic proximity Read ↗

Large-scale analysis of variation in the insulin-like growth factor family in humans reveals rare disease links and common polymorphisms.Semantic proximity Read ↗

Converting Insulin-like Growth Factors 1 and 2 into High-Affinity Ligands for Insulin Receptor Isoform A by the Introduction of an Evolutionarily Divergent Mutation.Semantic proximity Read ↗

Mutations at hypothetical binding site 2 in insulin and insulin-like growth factors 1 and 2.Semantic proximity Read ↗

Phylogeny of the insulin‐like growth factors (IGFS) and receptors: A molecular approachSemantic proximity Read ↗

How IGF-1 activates its receptor.Semantic proximity Read ↗

Insulin Receptor Isoforms and Insulin Growth Factor-like Receptors: Implications in Cell Signaling, Carcinogenesis, and ChemoresistanceSemantic proximity Read ↗

A Review of the Biosynthesis and Structural Implications of Insulin Gene Mutations Linked to Human Disease.Semantic proximity Read ↗

Novel Insulin-Like Growth Factor 1 Gene Mutation: Broadening of the Phenotype and Implications for Insulin Resistance.Semantic proximity Read ↗

Design of an insulin analog with enhanced receptor binding selectivity: rationale, structure, and therapeutic implications.Semantic proximity Read ↗

A database and website for molecular defects of the GH-IGF axis: www.growthgenetics.com.Semantic proximity Read ↗

Functional characterization of a clinically significant variant of IGF1R (M1054I) - a critical residue involved in defining the binding of small molecules in the allosteric pocket of IGF1R.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.