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Article

Evaluating genomic polygenic risk scores for childhood acute lymphoblastic leukemia in Latinos.

HGG advances - 12 Oct 2023

Jeon Soyoung, Lo Ying Chu, Morimoto Libby M, Metayer Catherine, Ma Xiaomei, Wiemels Joseph L, de Smith Adam J, Chiang Charleston W K

Abstract excerpt

The utility of polygenic risk score (PRS) models has not been comprehensively evaluated for childhood acute lymphoblastic leukemia (ALL), the most common type of cancer in children. Previous PRS models for ALL were based on significant loci observed in genome-wide association studies (GWASs), even though genomic PRS models have been shown to improve prediction performance for a number of complex diseases. In the...

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Identifiers

PMID: 37710962
DOI: 10.1016/j.xhgg.2023.100239
PMCID: PMC10550840

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