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Article

Effect of mutations on the folding and stability of γD-crystallin protein.

Journal of biomolecular structure & dynamics - 1 Jan 2024

Ghosh Deepshikha, Sojitra Kandarp Ashokbhai, Biswas Anushka, Agarwal Manish, Radhakrishna Mithun

Abstract excerpt

Interprotein interactions between the partially unfolded states of γD-crystallin (γD-crys) protein are known to cause cataracts. Therefore, understanding the unfolding pathways of native γD-crys is extremely crucial to delineate their aggregation mechanism. In this study, we have performed extensive all-atom Molecular Dynamics simulations with explicit solvent to understand the role of the critical residues that...

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Source

Identifiers

PMID: 37830785
DOI: 10.1080/07391102.2023.2266768

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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