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Constant pH molecular dynamics (CpHMD) and mutation studies: insights into AaegOBP1 pH-induced ligand releasing mechanism.

Biochimica et biophysica acta - 1 Jul 2012

Chu Wen-Ting, Wu Yun-Jian, Zhang Ji-Long, Zheng Qing-Chuan, Chen Lin, Xue Qiao, Zhang Hong-Xing

Abstract excerpt

AaegOBP1, isolated from the male and female antenna of yellow fever mosquitoes, may serve as crucial molecular targets for the development of mosquitoes' attractants and for the control of mosquito populations. Nowadays crystal structures of AaegOBP1 in the neutral environment have been obtained, whereas little research is focused on the conformational change of AaegOBP1 in the acid solution. In our study, the...

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PMID: 22575088
DOI: 10.1016/j.bbapap.2012.03.008

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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