Article
Opening of a cryptic pocket in β-lactamase increases penicillinase activity.
Proceedings of the National Academy of Sciences of the United States of America - 23 Nov 2021
Knoverek Catherine R, Mallimadugula Upasana L, Singh Sukrit, Rennella Enrico, Frederick Thomas E, Yuwen Tairan, Raavicharla Shreya, Kay Lewis E, Bowman Gregory R
Abstract excerpt
Understanding the functional role of protein-excited states has important implications in protein design and drug discovery. However, because these states are difficult to find and study, it is still unclear if excited states simply result from thermal fluctuations and generally detract from function or if these states can actually enhance protein function. To investigate this question, we consider excited states...
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