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Article

Integration of the immune memory into the pathogen-driven MHC polymorphism hypothesis.

HLA - 1 Dec 2023

Radwan Jacek, Kohi Chirine, Ejsmond Maciej, Paganini Julien, Pontarotti Pierre

Abstract excerpt

Major histocompatibility complex (MHC) genes (referred to as human leukocyte antigen or HLA in humans) are a key component of vertebrate immune systems, coding for proteins which present antigens to T-cells. These genes are outstanding in their degree of polymorphism, with important consequences for human and animal health. The polymorphism is thought to arise from selection pressures imposed by pathogens on MHC...

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PMID: 37688391
DOI: 10.1111/tan.15216

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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