Article
The molecular descent of the major histocompatibility complex.
Annual review of immunology - 1 Jan 1993
Klein J, Satta Y, O'hUigin C, Takahata N
Abstract excerpt
In the last few years, more than 500 primate major histocompatibility complex (Mhc) genes or parts thereof have been sequenced. The extraordinary sequence information is used here to draw conclusions about the manner of Mhc evolution. The Mhc genes are found to evolve at a relatively slow rate with the regularity of a clock. It takes from 1 to 6 million years for a new mutation to be incorporated into an Mhc...
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