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Article

COVID-19 Pandemic: Escape of Pathogenic Variants and MHC Evolution.

International journal of molecular sciences - 28 Feb 2022

Pontarotti Pierre, Paganini Julien

Abstract excerpt

We propose a new hypothesis that explains the maintenance and evolution of MHC polymorphism. It is based on two phenomena: the constitution of the repertoire of naive T lymphocytes and the evolution of the pathogen and its impact on the immune memory of T lymphocytes. Concerning the latter, pathogen evolution will have a different impact on reinfection depending on the MHC allomorph. If a mutation occurs in a...

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Identifiers

PMID: 35269808
DOI: 10.3390/ijms23052665
PMCID: PMC8910380

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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