Article

2P-FLIM unveils time-dependent metabolic shifts during osteogenic differentiation with a key role of lactate to fuel osteogenesis via glutaminolysis identified

2023-04-10

Abstract excerpt

<title>Abstract</title> <p>I. <italic><bold>Background</bold></italic>: Human mesenchymal stem cells (hMSCs) fuel discrete biosynthetic pathways to multiply and differentiate into specific cell lineages; with undifferentiated hMSCs showing reliance on glycolytic respiration. hMSCs differentiating towards an osteogenic phenotype rely on oxidative phosphorylation as an energy source. Two-photon fluorescence lifetim...

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Literature Corpus work: 8353d7c9-f04c-5be4-a30c-a2ec284ce690
DOI: 10.21203/rs.3.rs-2585806/v1

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