Article

Persistent glycolysis defines the foreign body response to polymeric implants

2025-02-08

Abstract excerpt

Non-degradable polymeric implantable medical devices are a mainstay of modern healthcare but can frequently lead to severe complications. These complications are largely attributable to the foreign body response ( FBR ), which is characterized by excessive inflammation and fibrosis in response to implanted materials. The pathologic mechanisms underpinning the FBR remain elusive; however, metabolism is increasingl...

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Literature Corpus work: 53f9a568-159e-57a6-aa00-f725569de566
DOI: 10.1101/2025.02.04.636531

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