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Acute Myeloid Leukaemia with Normal Cytogenetics and NPM1-Mutation:  Impact of Mutation Topography on Outcomes

2024-05-03

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<title>Abstract</title> <p>Background About one-half of adults with acute myeloid leukaemia with normal cytogenetics (CN-AML) have a nucleophosmin-1 (<italic>NPM1</italic>) mutation. There is controversy regarding their prognosis and best therapy. Methods We studied 150 consecutive subjects with these features using targeted regional sequencing. The co-variates in the multi-variable analyses including clinical...

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Literature Corpus work
db3ee0cf-52b0-5322-9199-7153fb5569a1
DOI
10.21203/rs.3.rs-4318548/v1
Open publication

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Acute Myeloid Leukaemia with Normal Cytogenetics and NPM1-Mutation: Impact of Mutation Topography on OutcomesDOI 10.21203/rs.3.rs-4318548/v1
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