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Nucleophosmin 1 (NPM1) mutations in chronic myelomonocytic leukemia and their prognostic relevance

14 Jul 2017

Abstract excerpt

Chronic myelomonocytic leukemia (CMML) is an aggressive hematologic malignancy with overlapping features of myelodysplastic syndromes (MDS) and myeloproliferative neoplasms.1, 2 Patients with CMML, display between 10 and 15 mutations per kilobase of coding DNA regions; with majority of these (>90%) involving epigenetic regulator genes (TET2 60%, ASXL1 40%), splicing machinery (SRSF2 40%), and cell signaling...

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PMID: 28707414
DOI: 10.1002/ajh.24861

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