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Article

The importance of escalating molecular diagnostics in patients with low-grade pediatric brain cancer.

Cold Spring Harbor molecular case studies - 1 Dec 2023

Al Assaad Majd, Gundem Gunes, Liechty Benjamin, Sboner Andrea, Medina Juan, Papaemmanuil Elli, Sternberg Cora N, Marks Asher, Souweidane Mark M, Greenfield Jeffrey P, Tran Ivy, Snuderl Matija, Elemento Olivier, Imielinski Marcin, Pisapia David J, Mosquera Juan Miguel

Abstract excerpt

Pilocytic astrocytomas are the most common pediatric brain tumors, typically presenting as low-grade neoplasms. We report two cases of pilocytic astrocytoma with atypical tumor progression. Case 1 involves a 12-yr-old boy with an unresectable suprasellar tumor, negative for BRAF rearrangement but harboring a BRAF p.V600E mutation. He experienced tumor size reduction and stable disease following dabrafenib...

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Identifiers

PMID: 37652664
DOI: 10.1101/mcs.a006275
PMCID: PMC10815291

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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