Article
Integrating molecular analyses with the 2021 WHO classification of adult pilocytic astrocytomas.
Journal of neuropathology and experimental neurology - 21 Feb 2025
Moreno-Torres Beatriz, Manzano-Benito Irene, Cantero Diana, Romo Ángel, de Lope Ángel Rodríguez, Mollejo Manuela, Hernández-Laín Aurelio, Meléndez Bárbara
Abstract excerpt
Pilocytic astrocytomas (PAs) are benign grade 1 gliomas according to the World Health Organization (WHO). They are common in children but rare in adults in whom they may have a worse prognosis. Pediatric PAs are usually associated with dysregulation of the mitogen-activated protein kinase (MAPK) pathway, often involving BRAF alterations such as the KIAA1549::BRAF (K-B) fusion or V600E mutation. We investigated...
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