Article
Integrated molecular and clinical analysis of low-grade gliomas in children with neurofibromatosis type 1 (NF1).
Acta neuropathologica - 1 Apr 2021
Fisher Michael J, Jones David T W, Li Yimei, Guo Xiaofan, Sonawane Poonam S, Waanders Angela J, Phillips Joanna J, Weiss William A, Resnick Adam C, Gosline Sara, Banerjee Jineta, Guinney Justin, Gnekow Astrid, Kandels Daniela, Foreman Nicholas K, Korshunov Andrey, Ryzhova Marina, Massimi Luca, Gururangan Sri, Kieran Mark W, Wang Zhihong, Fouladi Maryam, Sato Mariko, Øra Ingrid, Holm Stefan, Markham Stephen J, Beck Pengbo, Jäger Natalie, Wittmann Andrea, Sommerkamp Alexander C, Sahm Felix, Pfister Stefan M, Gutmann David H
Abstract excerpt
Low-grade gliomas (LGGs) are the most common childhood brain tumor in the general population and in individuals with the Neurofibromatosis type 1 (NF1) cancer predisposition syndrome. Surgical biopsy is rarely performed prior to treatment in the setting of NF1, resulting in a paucity of tumor genomic information. To define the molecular landscape of NF1-associated LGGs (NF1-LGG), we integrated clinical data,...
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