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Pediatric High-Grade Astrocytoma With Piloid Features: A Comprehensive Literature Review.

Pediatric blood & cancer - 1 Mar 2026

Kokossis Danae, Mian Ali, Crumley Brenndan, Dahiya Sonika, Abdelbaki Mohamed S

Abstract excerpt

BACKGROUND: High-grade astrocytoma with piloid features (HGAP) is a recently defined central nervous system (CNS) tumor, first introduced into the 2021 World Health Organization (WHO) classification. While predominantly observed in adults, pediatric cases remain rare and poorly characterized. This study aimed to review the epidemiology, clinical features, and molecular profile of pediatric HGAP. METHODS: A...

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Adolescent
Astrocytoma
Brain Neoplasms
Child
Child, Preschool
DNA Methylation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Neoplasm Grading

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Identifiers

PMID: 41549586
DOI: 10.1002/1545-5017.70072

Genes

ATRX
CDKN2A
FGFR1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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