Article
Evaluation of KRAS and NRAS mutations in metastatic colorectal cancer: an 8-year study of 10 754 patients in Turkey.
Molecular oncology - 1 Oct 2025
Kavgaci Gozde, Akiva Izzet, Ozon Yavuz Hakan, Berkil Hakan, Karadayi Huseyin, Dizdar Omer, Yalcin Suayib
Abstract excerpt
This study aimed to evaluate KRAS and NRAS mutations over an eight-year period to provide a comprehensive understanding of the genetic landscape of metastatic colorectal cancer (mCRC) in Turkish patients. Tumor tissue samples were collected from 10 754 patients with mCRC between January 2015 and June 2023 from multiple centers across Turkey, and all genetic analyses were performed at a single facility. DNA was...
Topics
- Humans
- Colorectal Neoplasms
- Turkey
- GTP Phosphohydrolases
- Membrane Proteins
- Proto-Oncogene Proteins p21(ras)
- Female
- Male
- Mutation
- Middle Aged
- Aged
- Neoplasm Metastasis
- Adult
- Aged, 80 and over