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Structural basis of telomeric nucleosome recognition by shelterin factor TRF1

25 Aug 2023

Abstract excerpt

Shelterin and nucleosomes are the key players that organize mammalian chromosome ends into the protective telomere caps. However, how they interact with each other at telomeres remains unknown. We report cryo-electron microscopy structures of a human telomeric nucleosome both unbound and bound to the shelterin factor TRF1. Our structures reveal that TRF1 binds unwrapped nucleosomal DNA ends by engaging both the...

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Share to DNA Repair Mechanisms
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PMID: 37624885
DOI: 10.1126/sciadv.adi4148

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Structural basis of telomeric nucleosome recognition by shelterin factor TRF1PMID 37624885Read ↗

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