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Article

TRF2 Recruits RTEL1 to Telomeres in S Phase to Promote T-Loop Unwinding

22 Jan 2015

Abstract excerpt

The helicase RTEL1 promotes t-loop unwinding and suppresses telomere fragility to maintain the integrity of vertebrate telomeres. An interaction between RTEL1 and PCNA is important to prevent telomere fragility, but how RTEL1 engages with the telomere to promote t-loop unwinding is unclear. Here, we establish that the shelterin protein TRF2 recruits RTEL1 to telomeres in S phase, which is required to prevent...

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Identifiers

PMID: 25620558
DOI: 10.1016/j.molcel.2014.12.024

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Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

TRF2 Recruits RTEL1 to Telomeres in S Phase to Promote T-Loop UnwindingPMID 25620558Read ↗

Inherited mutations in the helicase RTEL1 cause telomere dysfunction and Hoyeraal-Hreidarsson syndrome.Semantic proximity Read ↗

Mutations of the RTEL1 Helicase in a Hoyeraal-Hreidarsson Syndrome Patient Highlight the Importance of the ARCH Domain.Semantic proximity Read ↗

The many faces of the helicase RTEL1 at telomeres and beyond.Semantic proximity Read ↗

ZNF524 directly interacts with telomeric DNA and supports telomere integritySemantic proximity Read ↗

CDK phosphorylation of TRF2 controls t-loop dynamics during the cell cycle.Semantic proximity Read ↗

RTEL1: functions of a disease-associated helicase.Semantic proximity Read ↗

The Werner Syndrome Helicase and Exonuclease Cooperate to Resolve Telomeric D Loops in a Manner Regulated by TRF1 and TRF2Semantic proximity Read ↗

Rapid dynamics allow the low-abundance RTEL1 helicase to promote telomere replicationSemantic proximity Read ↗

SLX4 Assembles a Telomere Maintenance Toolkit by Bridging Multiple Endonucleases with TelomeresSemantic proximity Read ↗

Telomeres: Structures in need of unwindingSemantic proximity Read ↗

TRF2 Mediates Replication Initiation within Human Telomeres to Prevent Telomere DysfunctionSemantic proximity Read ↗

Full length RTEL1 is required for the elongation of the single-stranded telomeric overhang by telomeraseSemantic proximity Read ↗

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