Prognostic Biomarkers and Immunotherapeutic Insights of Circulating Tumor DNA Analysis in Advanced Esophageal Squamous Cell Carcinoma From SCRUM-MONSTAR GOZILA Substudy.

doi:10.1200/PO-25-00971

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Prognostic Biomarkers and Immunotherapeutic Insights of Circulating Tumor DNA Analysis in Advanced Esophageal Squamous Cell Carcinoma From SCRUM-MONSTAR GOZILA Substudy.

JCO precision oncology - 1 Mar 2026

Duan Yuqing, Hashimoto Tadayoshi, Shibuki Taro, Taniguchi Hiroya, Sunakawa Yu, Komatsu Yoshito, Takahashi Naoki, Sato Yuta, Yamaguchi Kensei, Nishina Tomohiro, Nakanoko Tomonori, Boku Shogen, Satoh Taroh, Yasui Hisateru, Esaki Taito, Imai Mitsuho, Fujisawa Takao, Nakamura Yoshiaki, Bando Hideaki, Yoshino Takayuki

Abstract excerpt

PURPOSE: Advanced esophageal squamous cell carcinoma (ESCC) has a poor prognosis, and current treatments provide limited survival benefits. This study aimed to identify prognostic biomarkers and therapeutic targets by genomic profiling of advanced ESCC using circulating tumor DNA (ctDNA). METHODS: The SCRUM-MONSTAR GOZILA study is a nationwide, plasma-based molecular profiling project using Guardant360, involving...

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PMID: 41911515
DOI: 10.1200/PO-25-00971
PMCID: PMC13048326

Genes

EGFR
FGFR1
NFE2L2
PIK3CA
CCND1
RB1
TP53

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