Article
Clinical utility of circulating tumor DNA sequencing in advanced gastrointestinal cancer: SCRUM-Japan GI-SCREEN and GOZILA studies.
Nature medicine - 1 Dec 2020
Nakamura Yoshiaki, Taniguchi Hiroya, Ikeda Masafumi, Bando Hideaki, Kato Ken, Morizane Chigusa, Esaki Taito, Komatsu Yoshito, Kawamoto Yasuyuki, Takahashi Naoki, Ueno Makoto, Kagawa Yoshinori, Nishina Tomohiro, Kato Takeshi, Yamamoto Yoshiyuki, Furuse Junji, Denda Tadamichi, Kawakami Hisato, Oki Eiji, Nakajima Takako, Nishida Naohiro, Yamaguchi Kensei, Yasui Hisateru, Goto Masahiro, Matsuhashi Nobuhisa, Ohtsubo Koushiro, Yamazaki Kentaro, Tsuji Akihito, Okamoto Wataru, Tsuchihara Katsuya, Yamanaka Takeharu, Miki Izumi, Sakamoto Yasutoshi, Ichiki Hiroko, Hata Masayuki, Yamashita Riu, Ohtsu Atsushi, Odegaard Justin I, Yoshino Takayuki
Abstract excerpt
Comprehensive genomic profiling enables genomic biomarker detection in advanced solid tumors. Here, to evaluate the utility of circulating tumor DNA (ctDNA) genotyping, we compare trial enrollment using ctDNA sequencing in 1,687 patients with advanced gastrointestinal (GI) cancer in SCRUM-Japan GOZILA (no. UMIN000016343), an observational ctDNA-based screening study, to enrollment using tumor tissue sequencing in...
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