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Article

Engineered MED12 mutations drive leiomyoma-like transcriptional and metabolic programs by altering the 3D genome compartmentalization.

Nature communications - 10 Jul 2023

Buyukcelebi Kadir, Chen Xintong, Abdula Fatih, Elkafas Hoda, Duval Alexander James, Ozturk Harun, Seker-Polat Fidan, Jin Qiushi, Yin Ping, Feng Yue, Bulun Serdar E, Wei Jian Jun, Yue Feng, Adli Mazhar

Abstract excerpt

Nearly 70% of Uterine fibroid (UF) tumors are driven by recurrent MED12 hotspot mutations. Unfortunately, no cellular models could be generated because the mutant cells have lower fitness in 2D culture conditions. To address this, we employ CRISPR to precisely engineer MED12 Gly44 mutations in UF-relevant myometrial smooth muscle cells. The engineered mutant cells recapitulate several UF-like cellular,...

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Identifiers

PMID: 37429859
DOI: 10.1038/s41467-023-39684-y
PMCID: PMC10333368

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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