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Article

Base Editor Scanning Reveals Activating Mutations of DNMT3A.

ACS chemical biology - 15 Sept 2023

Garcia Emma M, Lue Nicholas Z, Liang Jessica K, Lieberman Whitney K, Hwang Derek D, Woods James C, Liau Brian B

Abstract excerpt

DNA methyltransferase 3A (DNMT3A) is a de novo cytosine methyltransferase responsible for establishing proper DNA methylation during mammalian development. Loss-of-function (LOF) mutations to DNMT3A, including the hotspot mutation R882H, frequently occur in developmental growth disorders and hematological diseases, including clonal hematopoiesis and acute myeloid leukemia. Accordingly, identifying mechanisms that...

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Identifiers

PMID: 37603861
DOI: 10.1021/acschembio.3c00257
PMCID: PMC10560492

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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