Article

Base Editor Scanning Reveals Activating Mutations of DNMT3A

2023-04-13

Abstract excerpt

DNA methyltransferase 3A (DNMT3A) is a de novo cytosine methyltransferase responsible for establishing proper DNA methylation during mammalian development. Loss-of-function (LOF) mutations to DNMT3A, including the hotspot mutation R882H, frequently occur in developmental growth disorders and hematological diseases, including clonal hematopoiesis (CH) and acute myeloid leukemia (AML). Accordingly, identifying mech...

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Literature Corpus work: 350eb426-5de3-5257-bff3-cf5478be012d
DOI: 10.1101/2023.04.12.536656

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