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Article

Tumor mutational burden predicts neoantigen profiles and immunotherapy response in microsatellite stable tumors across different cancer types.

Frontiers in immunology - 1 Jan 2025

Kondrateva Olesia, Sonay Tugce Bilgin, Zlobec Inti, Anisimova Maria

Abstract excerpt

Introduction: Immunotherapy has shown positive response in many patients with microsatellite instable (MSI-H) tumors, but its effectiveness in microsatellite stable (MSS) tumors remains limited. We hypothesize that tumor mutational burden (TMB) can help identify a biologically distinct subset of MSS tumors that can benefit from immunotherapy. Methods: We analyzed the molecular characteristics, including...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41583482
DOI: 10.3389/fimmu.2025.1582464
PMCID: PMC12824007

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