Article
Multilevel genomics of colorectal cancers with microsatellite instability-clinical impact of JAK1 mutations and consensus molecular subtype 1.
Genome medicine - 24 May 2017
Sveen Anita, Johannessen Bjarne, Tengs Torstein, Danielsen Stine A, Eilertsen Ina A, Lind Guro E, Berg Kaja C G, Leithe Edward, Meza-Zepeda Leonardo A, Domingo Enric, Myklebost Ola, Kerr David, Tomlinson Ian, Nesbakken Arild, Skotheim Rolf I, Lothe Ragnhild A
Abstract excerpt
BACKGROUND: Approximately 15% of primary colorectal cancers have DNA mismatch repair deficiency, causing a complex genome with thousands of small mutations-the microsatellite instability (MSI) phenotype. We investigated molecular heterogeneity and tumor immunogenicity in relation to clinical endpoints within this distinct subtype of colorectal cancers. METHODS: A total of 333 primary MSI+ colorectal tumors from...
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