Article
HLA Class I Analysis Provides Insight Into the Genetic and Epigenetic Background of Immune Evasion in Colorectal Cancer With High Microsatellite Instability.
Gastroenterology - 1 Mar 2022
Kawazu Masahito, Ueno Toshihide, Saeki Koichi, Sax Nicolas, Togashi Yosuke, Kanaseki Takayuki, Chida Keigo, Kishigami Fumishi, Sato Kazuhito, Kojima Shinya, Otsuka Masafumi, Kawazoe Akihito, Nishinakamura Hitomi, Yuka Maeda, Yamamoto Yoko, Yamashita Kazuo, Inoue Satoshi, Tanegashima Tokiyoshi, Matsubara Daisuke, Tane Kenta, Tanaka Yosuke, Iinuma Hisae, Hashiguchi Yojiro, Hazama Shoichi, Khor Seik-Soon, Tokunaga Katsushi, Tsuboi Masahiro, Niki Toshiro, Eto Masatoshi, Shitara Kohei, Torigoe Toshihiko, Ishihara Soichiro, Aburatani Hiroyuki, Haeno Hiroshi, Nishikawa Hiroyoshi, Mano Hiroyuki
Abstract excerpt
BACKGROUND & AIMS: A detailed understanding of antitumor immunity is essential for optimal cancer immune therapy. Although defective mutations in the B2M and HLA-ABC genes, which encode molecules essential for antigen presentation, have been reported in several studies, the effects of these defects on tumor immunity have not been quantitatively evaluated. METHODS: Mutations in HLA-ABC genes were analyzed in 114...
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