Absence of the tag polymorphism for the risk haplotype HLA-DR2 for multiple sclerosis in Wixárika subjects from Mexico.

doi:10.1007/s00251-018-1052-8

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Article

Absence of the tag polymorphism for the risk haplotype HLA-DR2 for multiple sclerosis in Wixárika subjects from Mexico.

Immunogenetics - 1 Aug 2018

González-Enríquez G V, Torres-Mendoza B M, Márquez-Pedroza J, Macías-Islas M A, Ortiz G G, Cruz-Ramos J A

Abstract excerpt

The HLA-DRB1*15:01 allele has a demonstrated risk for the development of multiple sclerosis (MS) in most populations around the world. The single nucleotide polymorphism (SNP) rs3129934 is found in linkage disequilibrium with the risk haplotype formed by the HLA-DRB1*15:01 and HLA-DQB1*06:02 alleles, and it is considered a reliable marker of the presence of this haplotype. Native Americans have a null or low...

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PMID: 29397401
DOI: 10.1007/s00251-018-1052-8

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