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Article

Contributions of vitamin D response elements and HLA promoters to multiple sclerosis risk.

Neurology - 7 Aug 2012

Nolan David, Castley Alison, Tschochner Monika, James Ian, Qiu Wei, Sayer David, Christiansen Frank T, Witt Campbell, Mastaglia Frank, Carroll William, Kermode Allan

Abstract excerpt

OBJECTIVE: The identification of a vitamin D-responsive (VDRE) motif within the HLA-DRB1*15:01 promoter region provides an attractive explanation for the combined effects of HLA-DR inheritance and vitamin D exposure on multiple sclerosis (MS) risk. We therefore sought to incorporate HLA-DRB1 promoter variation, including the VDRE motif, in an assessment of HLA-DRB1-associated MS risk. METHODS: We utilized 32...

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Share to Alleles
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to HLA-DRB1 Chains

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Identifiers

PMID: 22786591
DOI: 10.1212/WNL.0b013e318263c407

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