Article
Vitamin D3 receptor ( VDR ) gene rs2228570 (Fok1) and rs731236 (Taq1) variants are not associated with the risk for multiple sclerosis: results of a new study and a meta-analysis.
PloS one - 1 Jan 2013
García-Martín Elena, Agúndez José A G, Martínez Carmen, Benito-León Julián, Millán-Pascual Jorge, Calleja Patricia, Díaz-Sánchez María, Pisa Diana, Turpín-Fenoll Laura, Alonso-Navarro Hortensia, Ayuso-Peralta Lucía, Torrecillas Dolores, Plaza-Nieto José Francisco, Jiménez-Jiménez Félix Javier
Abstract excerpt
BACKGROUND: Some epidemiological, genetic, and experimental data suggest a possible role of vitamin D in the pathogenesis of multiple sclerosis (MS) and in experimental autoimmune encephalomyelitis. Data on the possible contribution of several single nucleotide polymorphisms (SNP) in the vitamin D receptor (VDR) gene to the risk for MS are controversial. Several studies suggested an interaction between some SNPs...
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