Germline EGFR Mutations and Familial Lung Cancer.

doi:10.1200/JCO.23.01372

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Germline EGFR Mutations and Familial Lung Cancer.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 1 Dec 2023

Oxnard Geoffrey R, Chen Ruthia, Pharr Jennifer C, Koeller Diane R, Bertram Arrien A, Dahlberg Suzanne E, Rainville Irene, Shane-Carson Kate, Taylor Kelly A, Sable-Hunt Alicia, Sholl Lynette M, Teerlink Craig C, Thomas Alun, Cannon-Albright Lisa A, Fay André P, Ashton-Prolla Patrícia, Yang Hao, Salvatore Mary M, Addario Bonnie J, Jänne Pasi A, Carbone David P, Wiesner Georgia L, Garber Judy E

Abstract excerpt

PURPOSE: The genomic underpinnings of inherited lung cancer risk are poorly understood. This prospective study characterized the clinical phenotype of patients and families with germline EGFR pathogenic variants (PVs). METHODS: The Investigating Hereditary Risk from T790M study (ClinicalTrials.gov identifier: NCT01754025) enrolled patients with lung cancer whose tumor profiling harbored possible germline EGFR PVs...

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PMID: 37579253
DOI: 10.1200/JCO.23.01372
PMCID: PMC12153668

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EGFR

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