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Germline EGFR c.2527G > A (p.V843I) variant and familial lung cancer.

Lung cancer (Amsterdam, Netherlands) - 1 Jul 2023

Alsaddah Saba, Papadakis Andreas I, Wong Nora, Palma Laura, Szlachtycz David, Cruz Marino Tania, Fiset Pierre-Olivier, Foulkes William D

Abstract excerpt

BACKGROUND: Somatic epidermal growth factor receptor (EGFR) pathogenic variants have been identified and are routinely tested in the molecular diagnosis of non-small cell lung cancer (NSCLC) as they represent a target for EGFR tyrosine kinase inhibitor (TKI) therapy. However, germline variants in EGFR are much less frequently reported. CASE PRESENTATION: Herein, we report the case of a 46-year-old woman diagnosed...

Topics

Female
Humans
Adult
Middle Aged
Lung Neoplasms
Carcinoma, Non-Small-Cell Lung
Protein Kinase Inhibitors
ErbB Receptors
Adenocarcinoma of Lung
Lung
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37209596
DOI: 10.1016/j.lungcan.2023.107247

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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